購(gòu)物車(chē)
幫助
021-54845833/15800441009
技術(shù)規(guī)格
Background:
This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D); a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [
Applications:
WB, IHC, IF
Name of antibody:
KLHL3
Immunogen:
Synthesized peptide derived from N-terminal of human KLHL3.
Full name:
kelch-like family member 3
Synonyms：
PHA2D
SwissProt:
Q9UH77/Q8N4I8
IHC positive control:
Human brain tissue
IHC Recommend dilution:
50-100
WB Predicted band size:
65 kDa
WB Positive control:
RAW264.7 cells and NIH/3T3 cells lysates
WB Recommended dilution:
500-3000
IF positive control:
A549 cells
IF Recommend dilution:
100-500
