Name: F7抗原（重組蛋白）
Brand: 通蔚生物

中文名稱(chēng)： F7抗原（重組蛋白）

英文名稱(chēng)： F7 Antigen (Recombinant Protein)

別名： SPCA

儲(chǔ) 存： 冷凍（-20℃）

相關(guān)類(lèi)別：抗原

概述

Fusion protein corresponding to a region derived from C terminal 250 amino acids of human F7

技術(shù)規(guī)格

Full name:	coagulation factor VII (serum prothrombin conversion accelerator)
Synonyms:	SPCA
Swissprot:	P08709
Gene Accession:	BC130468
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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