Name: PTCH1抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： PTCH1抗原（重組蛋白）

英文名稱： PTCH1 Antigen (Recombinant Protein)

別名： PTC, BCNS, HPE7, PTC1, PTCH, NBCCS, PTCH11

儲存：冷凍（-20℃）

相關(guān)類別：抗原

概述

Fusion protein corresponding to a region derived from 1-183 amino acids of human PTCH1

技術(shù)規(guī)格

Full name:	patched 1
Synonyms:	PTC, BCNS, HPE7, PTC1, PTCH, NBCCS, PTCH11
Swissprot:	Q13635
Gene Accession:	BC043542
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

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