購(gòu)物車
幫助
021-54845833/15800441009
中文名稱： 兔抗NCF4多克隆抗體
英文名稱： Anti-NCF4 rabbit polyclonal antibody
別 名： MGC3810; NCF; P40PHOX; SH3PXD4
相關(guān)類別： 一抗
儲(chǔ) 存： 冷凍（-20℃） 避光
宿 主： Rabbit
抗 原： NCF4
反應(yīng)種屬： Human, Mouse, Rat
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
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Applications: |
WB |
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Name of antibody: |
NCF4 |
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Immunogen: |
Fusion protein of human NCF4 |
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Full name: |
neutrophil cytosolic factor 4, 40kDa |
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Synonyms： |
MGC3810; NCF; P40PHOX; SH3PXD4 |
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SwissProt: |
Q15080 |
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WB Predicted band size: |
39 kDa |
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WB Positive control: |
K562 cells |
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WB Recommended dilution: |
500-2000 |
