購(gòu)物車(chē)
幫助
021-54845833/15800441009
中文名稱(chēng)： 兔抗NLRP3多克隆抗體
英文名稱(chēng)： Anti-NLRP3 rabbit polyclonal antibody
別 名： AII; AVP; FCU; MWS; FCAS; CIAS1; NALP3; C1orf7; CLR1.1; PYPAF1; AGTAVPRL
儲(chǔ) 存： 冷凍（-20℃）
宿 主： Rabbit
抗 原： NLRP3
相關(guān)類(lèi)別： 一抗
反應(yīng)種屬： Human
標(biāo) 記 物： Unconjugate
克隆類(lèi)型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
NLRP3 |
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Immunogen: |
Fusion protein of human NLRP3 |
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Full name: |
NLR family, pyrin domain containing 3 |
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Synonyms： |
AII; AVP; FCU; MWS; FCAS; CIAS1; NALP3; C1orf7; CLR1.1; PYPAF1; AGTAVPRL |
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SwissProt: |
Q96P20 |
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ELISA Recommended dilution: |
1000-2000 |
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IHC positive control: |
Human esophagus cancer and human thyroid cancer |
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IHC Recommend dilution: |
15-50 |
