購(gòu)物車(chē)
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021-54845833/15800441009
中文名稱(chēng)： 兔抗PLAU多克隆抗體
英文名稱(chēng)： Anti-PLAU rabbit polyclonal antibody
別 名： ATF; QPD; UPA; URK; u-PA; BDPLT5
抗 原： PLAU
儲(chǔ) 存： 冷凍（-20℃）
宿 主： Rabbit
相關(guān)類(lèi)別： 一抗
反應(yīng)種屬： Human
標(biāo) 記 物： Unconjugate
克隆類(lèi)型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
PLAU |
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Immunogen: |
Fusion protein of human PLAU |
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Full name: |
plasminogen activator, urokinase |
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Synonyms： |
ATF; QPD; UPA; URK; u-PA; BDPLT5 |
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SwissProt: |
P00749 |
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ELISA Recommended dilution: |
1000-2000 |
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IHC positive control: |
Human gastric cancer and Human brain |
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IHC Recommend dilution: |
10-50 |
