Background: |
This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. |
Applications: |
ELISA, IHC |
Name of antibody: |
GRAP |
Immunogen: |
Full length fusion protein |
Full name: |
GRB2-related adaptor protein |
SwissProt: |
Q13588 |
ELISA Recommended dilution: |
5000-10000 |
IHC positive control: |
Human gastric cancer and human breast cancer |
IHC Recommend dilution: |
30-150 |