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中文名稱：兔抗CAMSAP3多克隆抗體
英文名稱： Anti-CAMSAP3 rabbit polyclonal antibody
別 名： calmodulin regulated spectrin associated protein family member 3; NEZHA; PPP1R80; KIAA1543
相關(guān)類別： 一抗
儲 存： 冷凍（-20℃）
抗 原： CAMSAP3
宿 主： Rabbit
反應種屬： Human, Mouse
標 記 物： Unconjugate
克隆類型： rabbit polyclonal
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Background: |
Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:27802168, PubMed:26715742). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). |
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Applications: |
ELISA, IHC |
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Name of antibody: |
CAMSAP3 |
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Immunogen: |
Synthetic peptide of human CAMSAP3 |
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Full name: |
calmodulin regulated spectrin associated protein family member 3 |
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Synonyms: |
NEZHA; PPP1R80; KIAA1543 |
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SwissProt: |
Q9P1Y5 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human cervical cancer |
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IHC Recommend dilution: |
100-300 |
